Gadolinium contrast medium is generally very safe. To me it seems reasonable that some of these patients could be experiencing mild symptoms in the spectrum of nephrogenic systemic fibrosis (NSF). In patients with normal kidney function, most of the gadolinium contrast medium injected (over 90%) is passed out in the urine within 24 hours. Online support groups can provide a wealth of help and information for people who believe they have been affected by gadolinium toxicity. Side effects or reactions are uncommon, but can occur. “Gadolinium deposition disease” is the name we propose for a disease process observed in subjects with normal or near normal renal function who develop persistent symptoms that arise hours to 2 months after the administration of [gadolinium-based contrast agents (GBCAs)]. Gadolinium is a highly toxic heavy metal. One more thought from me… A condition I am very familiar with is actually called Overlap Syndrome, in which a patient has more than one of: Autoimmune hepatitis, Primary sclerosing cholangitis, and Primary biliary cirrhosis. Intense boring pain in bones or joints. Signs and symptoms of gadolinium toxicity or Gadolinium Deposition Disease include: Intense burning of the skin and skin substrate: This may be localized in the torso or extremities (arms or legs) or it may affect the entire body. The symptoms of GDD include bone pain and pain in the extremities, burning tissue type pain and brain fog. It is more common when linear GBCA is used. Conditions can also be founded upon t 3. Possibly, although as discussed in several references below, there is no conclusive scientific evidence that it exists. Gadolinium deposition disease occurs when gadolinium breaks free of its chelator and is deposited in the body instead of being cleared by the kidneys. Gadolinium Deposition Disease (GDD) results in the development of persistent symptoms anywhere from a few hours to several weeks after being injected with a GBCA. Disease : because individuals are sick from it. In patients with kidney problems, the substance is not removed completely leading to an increased risk of Gadolinium deposition disease. Gadolinium Deposition Disease is a progressive disease, with no known cure. Symptoms Associated With Gadolinium Deposition Disease … Patients presenting with gadolinium deposition disease may show signs and symptoms that somewhat follows a pattern similar but not identical, and also less severe, to those observed in nephrogenic systemic fibrosis. Gadolinium Deposition Disease. It must be chelated when used in the body. However, they are likely to be healed within 48 hours of injection. Is gadolinium deposition disease real? I like the disease to be clear from its name, and not somehow obscure, so: Gadolinium Deposition Disease The first critical diagnostic feature is that the disease has to arise shortly after the injection of the GBCA. Gadolinium deposition disease is a newly described and probably infrequent entity. Although research demonstrates deposition in brain tissues, no specific symptoms or diseases have been linked to this finding. The most common short-term side effects of Gadolinium are nausea, vomiting, itching or feeling of cold sensation at the place of injection. #2. The condition was only formally recognized within the past few years, so much research is needed to figure out how to more effectively treat the myriad of painful symptoms associated with gadolinium accumulation in the body. 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